Клинические и радиологические предикторы развития эпилепсии у пациентов с цереброваскулярной патологией: обзор литературы с систематическим анализом данных
Multimodal predictors of late post-stroke epilepsy based on structural neuroimaging and electrophysiological findings
Domain | Predictive Factors | Imaging / Diagnostic Modality | Prognostic Significance |
Lesion volume and type | Large ischemic infarcts | CT / MRI | Higher incidence of late epileptic seizures |
Extensive intracerebral hemorrhage | CT / MRI | Increased risk of post-stroke epilepsy | |
Hemorrhagic components | Hemorrhagic transformation of ischemic stroke | CT / MRI | Independent risk factor for late epilepsy |
Cortical siderosis | MRI (SWI) | Strong association with epileptogenesis | |
Cerebral microbleeds | MRI (SWI) | Marker of increased seizure susceptibility | |
Chronic structural brain changes | Post-stroke gliosis | MRI (T2/FLAIR) | Substrate for secondary epileptogenesis |
Cortical atrophy | MRI (volumetric / visual assessment) | Network disruption and seizure generation | |
Electrophysiological findings | Severe leukoaraiosis | MRI (FLAIR) | Impaired connectivity and increased epileptic risk |
Epileptiform discharges | EEG | Strong predictor of late epilepsy | |
Periodic lateralized discharges | EEG | Associated with higher seizure recurrence | |
Focal slowing in lesion area | EEG | Reflects cortical dysfunction and epileptogenicity | |
Integrated assessment | Combined clinical, radiological and EEG markers | Multimodal approach | Improved risk stratification and prediction accuracy |